• Vaccine Name: RSV-H7
• Target Pathogen: Influenza virus
• Target Disease: Influenza (flu)
• Vaccine Ontology ID: VO_0004724
• Type: Recombinant vector vaccine
• Status: Research
• Host Species for Licensed Use: Baboon
• HA gene engineering:
  • Type: Recombinant protein preparation
  • Description: Plasmid DNAs used for vector construction included pSV153, containing the H7 gene of Seal/Mass/80 (H7N7) (17) (Hunt et al., 1988).
  • Detailed Gene Information: Click Here.
• Vector:
  • Vector name:
  • VO vector ID: VO_0001104
• Preparation: The HA selected for expression was that of A/Seal/Mass/1/80 (H7N7) (Seal/Mass/80) (Hunt et al., 1988).
• Immunization Route: Intramuscular injection (i.m.)

Chicken Response

• Vaccination Protocol: A P1/H7 stock which expressed 5 to 10% of the level of H7 observed in influenza virus-infected chicken embryo fibroblasts was used to immunize 1-month-old chickens (Hunt et al., 1988).
• Vaccine Immune Response Type: VO_0003057
• Challenge Protocol: The chickens were inoculated via the nares with 10^4 EID50 of A/Chicken/Victoria/1/85 (H7N7) influenza virus (Hunt et al., 1988).
• Efficacy: This immunization resulted in low or undetectable levels of hemagglutination-inhibiting and neutralizing antibody. Despite the low serum response, challenge with a highly pathogenic H7N7 virus revealed complete protection against lethal infection (Hunt et al., 1988).