• Vaccine Name: pRP-RSV-HSV-1-gB
• Target Pathogen: Herpes simplex virus type 1 and 2
• Target Disease: Herpes
• Vaccine Ontology ID: VO_0004723
• Type: Recombinant vector vaccine
• Status: Research
• Host Species for Licensed Use: Baboon
• gB gene engineering:
  • Type: Recombinant vector construction
  • Description: The herpes simplex virus type 1 (HSV-1) glycoprotein B (gB-1) gene, was cloned under control of the Rous sarcoma virus long terminal repeat in the episomal replicating vector pRP-RSV (Manservigi et al., 1990).
  • Detailed Gene Information: Click Here.
• Vector:
  • Vector name:
  • VO vector ID: VO_0001104
• Preparation: The herpes simplex virus type 1 (HSV-1) glycoprotein B (gB-1) gene, deleted of 639 nucleotides that encode the transmembrane anchor sequence and reconstructed with the extramembrane and intracytoplasmic domains, was cloned under control of the Rous sarcoma virus long terminal repeat in the episomal replicating vector pRP-RSV (Manservigi et al., 1990).
• Immunization Route: Intramuscular injection (i.m.)

Mouse Response

• Vaccination Protocol: Mice were immunized with secreted gB-1 produced HSV-1- and HSV-2-neutralizing antibodies (Manservigi et al., 1990).
• Vaccine Immune Response Type: VO_0003057
• Challenge Protocol: Mice were challenged with HSV-1 or LV (Manservigi et al., 1990).
• Efficacy: Mice immunized with secreted gB-1 produced HSV-1- and HSV-2-neutralizing antibodies and were protected against HSV-1 lethal, latent, and recurrent infections (Manservigi et al., 1990).