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Vaccine Detail
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rVCG- Chlamydia-cholera |
| Vaccine Information |
- Vaccine Name: rVCG- Chlamydia-cholera
- Target Pathogen: Chlamydia trachomatis
- Target Disease: Chlamydia
- Vaccine Ontology ID: VO_0004720
- Type: Recombinant vector vaccine
- Status: Research
- Host Species for Licensed Use: Baboon
- Vector:
- Preparation: A multisubunit vaccine candidate co-expressing the serovar D-derived Porin B and polymorphic membrane protein-D proteins of Chlamydia trachomatis (Eko et al., 2011; Chen et al., 1998).
- Immunization Route: Intramuscular injection (i.m.)
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| Host Response |
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Mouse Response
- Vaccination Protocol: Mice were immunized with rVCG constructs (Eko et al., 2011).
- Vaccine Immune Response Type: VO_0003057
- Efficacy: All vaccinated mice responded with a significant rise in vibriocidal antibody titer, the surrogate marker for protection in cholera (Eko et al., 2011).
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| References |
Chen et al., 1998: Chen I, Finn TM, Yanqing L, Guoming Q, Rappuoli R, Pizza M. A recombinant live attenuated strain of Vibrio cholerae induces immunity against tetanus toxin and Bordetella pertussis tracheal colonization factor. Infection and immunity. 1998; 66(4); 1648-1653. [PubMed: 9529093].
Eko et al., 2011: Eko FO, Okenu DN, Singh UP, He Q, Black C, Igietseme JU. Evaluation of a broadly protective Chlamydia-cholera combination vaccine candidate. Vaccine. 2011; 29(21); 3802-3810. [PubMed: 21421002].
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