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Vaccine Detail

rCMV- EBOV
Vaccine Information
  • Vaccine Name: rCMV- EBOV
  • Target Pathogen: Ebola virus
  • Target Disease: Ebola hemorrhagic fever
  • Vaccine Ontology ID: VO_0004717
  • Type: Recombinant vector vaccine
  • Status: Research
  • Host Species for Licensed Use: Baboon
  • NP from Zaire Ebola virus gene engineering:
    • Type: Recombinant protein preparation
    • Description: A mouse CMV (MCMV) vector expressing a CD8+ T cell epitope from the nucleoprotein (NP) of Zaire ebolavirus (ZEBOV) (MCMV/ZEBOV-NP(CTL)) (Tsuda et al., 2011).
    • Detailed Gene Information: Click Here.
  • Vector:
  • Preparation: A mouse CMV (MCMV) vector expressing a CD8+ T cell epitope from the nucleoprotein (NP) of Zaire ebolavirus (ZEBOV) (MCMV/ZEBOV-NP(CTL)) (Tsuda et al., 2011).
  • Immunization Route: Intramuscular injection (i.m.)
Host Response

Mouse Response

  • Vaccination Protocol: Mice were vaccinated with rCMV- EBOV (Tsuda et al., 2011).
  • Vaccine Immune Response Type: VO_0003057
  • Challenge Protocol: Mice were challenged with a lethal dose of ZEBOV (Tsuda et al., 2011).
  • Efficacy: The vaccine induced high levels of long-lasting (>8 months) CD8+ T cells against ZEBOV NP in mice. Importantly, all vaccinated animals were protected against lethal ZEBOV challenge (Tsuda et al., 2011).
References
Tsuda et al., 2011: Tsuda Y, Caposio P, Parkins CJ, Botto S, Messaoudi I, Cicin-Sain L, Feldmann H, Jarvis MA. A replicating cytomegalovirus-based vaccine encoding a single Ebola virus nucleoprotein CTL epitope confers protection against Ebola virus. PLoS neglected tropical diseases. 2011; 5(8); e1275. [PubMed: 21858240].