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Vaccine Detail
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Maraba virus MG1 Vaccine |
| Vaccine Information |
- Vaccine Name: Maraba virus MG1 Vaccine
- Target Pathogen: Cancer
- Target Disease: Cancer
- Vaccine Ontology ID: VO_0004708
- Type: Recombinant vector vaccine
- Status: Research
- Host Species for Licensed Use: Baboon
- MUC5B
gene engineering:
- Type: Recombinant protein preparation
- Description: (Pol et al., 2014)
- Detailed Gene Information: Click Here.
- Vector:
- Preparation: An attenuated Maraba strain, defined as MG1, was used to express a melanoma-associated tumor antigen (Pol et al., 2014).
- Immunization Route: Intramuscular injection (i.m.)
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| Host Response |
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Mouse Response
- Vaccine Immune Response Type: VO_0000287
- Efficacy: Once applied for treating syngeneic murine melanoma tumors, our oncolytic prime-boost vaccination protocol involving Maraba MG1 dramatically extended median survival and allowed complete remission in more than 20% of the animals treated (Pol et al., 2014).
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| References |
Pol et al., 2014: Pol JG, Zhang L, Bridle BW, Stephenson KB, Rességuier J, Hanson S, Chen L, Kazdhan N, Bramson JL, Stojdl DF, Wan Y, Lichty BD. Maraba virus as a potent oncolytic vaccine vector. Molecular therapy : the journal of the American Society of Gene Therapy. 2014; 22(2); 420-429. [PubMed: 24322333].
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