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Vaccine Detail
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rAdV-SFV-E2 |
| Vaccine Information |
- Vaccine Name: rAdV-SFV-E2
- Target Pathogen: Classical swine fever virus
- Target Disease: Classical swine fever, hog cholera
- Vaccine Ontology ID: VO_0004700
- Type: Recombinant vector vaccine
- Status: Research
- Host Species for Licensed Use: Pig
- Vector:
- Preparation: An adenovirus-vectored Semliki forest virus replicon construct expressing the E2 glycoprotein from CSFV, rAdV-SFV-E2 (Sun et al., 2013).
- Immunization Route: Intramuscular injection (i.m.)
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| Host Response |
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Pig Response
- Vaccine Immune Response Type: VO_0003057
- Efficacy: Two immunizations with a dose as low as 6.25×10^5 TCID(50) or a single immunization with a dose of 10^7 TCID(50) rAdV-SFV-E2 provided complete protection against a lethal CSFV challenge (Sun et al., 2013).
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| References |
Sun et al., 2013: Sun Y, Tian DY, Li S, Meng QL, Zhao BB, Li Y, Li D, Ling LJ, Liao YJ, Qiu HJ. Comprehensive evaluation of the adenovirus/alphavirus-replicon chimeric vector-based vaccine rAdV-SFV-E2 against classical swine fever. Vaccine. 2013; 31(3); 538-544. [PubMed: 23153441].
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