• Vaccine Name: PrV-HA (swine-origin H1N1)
• Target Pathogen: Influenza virus
• Target Disease: Influenza (flu)
• Vaccine Ontology ID: VO_0004698
• Type: Recombinant vector vaccine
• Status: Research
• Host Species for Licensed Use: Baboon
• HA gene engineering:
  • Type: Recombinant protein preparation
  • Description: Pseudorabies virus (PrV) strain Bartha (PrV-Ba) served as a vector for the expression of haemagglutinin (HA) of swine-origin H1N1 virus (Klingbeil et al., 2014).
  • Detailed Gene Information: Click Here.
• Vector:
  • Vector name:
  • VO vector ID: VO_0001050
• Preparation: The pseudorabies virus (PrV) strain Bartha (PrV-Ba) was used as vector for the expression of haemagglutinin (HA) of swine-origin H1N1 virus (Klingbeil et al., 2014).
• Immunization Route: Intramuscular injection (i.m.)

Pig Response

• Vaccination Protocol: Piglets were infected intranasally with PrV-BaMI-synH1 as a live-virus vaccine, whereas control animals were immunized with PrV-Ba or not vaccinated (Klingbeil et al., 2014).
• Vaccine Immune Response Type: VO_0003057
• Challenge Protocol: A challenge with pandemic H1N1 SoIV A/California/7/09 performed 3 weeks after immunization (Klingbeil et al., 2014).
• Efficacy: A single immunization of pigs with the PrV vector expressing the codon-optimized HA gene under control of P-MCMV induced high levels of HA-specific antibodies (Klingbeil et al., 2014).