• Vaccine Name: YF17D- HIV-1 p24
• Target Pathogen: Human Immunodeficiency Virus
• Target Disease: Acquired Immunodeficiency Syndrome (AIDS)
• Vaccine Ontology ID: VO_0004690
• Type: Recombinant vector vaccine
• Status: Research
• Host Species for Licensed Use: Mouse
• Vector:
  • Vector name:
  • VO vector ID: VO_0000122
• Preparation: HIV-1 p24 (clade B consensus), was inserted near the 5' end of YF17D, in frame and upstream of the polyprotein (YF-5'/p24) (Franco et al., 2010).
• Immunization Route: Intramuscular injection (i.m.)

Mouse Response

• Vaccination Protocol: Mice were immunized two times subcutaneously at the base of the tail with PBS or 10^6 pfu of YF17D, YF-E/p24/NS1, or YF-5′/p24 in 100 μl on days 0 and 14 (Franco et al., 2010).
• Vaccine Immune Response Type: VO_0003057
• Challenge Protocol: Three weeks after the second immunization, half of the mice in each group were challenged intranasally with 5 × 10^5 pfu of Gag-expressing recombinant vaccinia virus (Vac-gag). The remaining animals in the groups were challenged intranasally with the same dose of wild-type vaccinia virus (Vac-wt) (Franco et al., 2010).
• Efficacy: The protective efficacy of the YF17D recombinants, particularly YF-E/p24/NS1, in mice challenged with a vaccinia expressing HIV-1 Gag was demonstrated (Franco et al., 2010).