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Vaccine Detail
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rNDV-H5 |
| Vaccine Information |
- Vaccine Name: rNDV-H5
- Target Pathogen: Influenza virus
- Target Disease: Influenza (flu)
- Vaccine Ontology ID: VO_0004681
- Type: Recombinant vector vaccine
- Status: Research
- Host Species for Licensed Use: Chicken
- Vector: Newcastle disease virus vaccine vector
- Preparation: Enterotropic NDV vector expressing an H5 haemagglutinin (rNDV-H5) (Ferreira et al., 2014).
- Immunization Route: Intramuscular injection (i.m.)
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| Host Response |
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Chicken Response
- Vaccination Protocol: 1-day-old specific pathogen free chickens inoculated once, twice or once with rNDV-H5 followed by a heterologous boost with an inactivated H5N9 vaccine (iH5N9) (Ferreira et al., 2014).
- Vaccine Immune Response Type: VO_0003057
- Challenge Protocol: The chicks were challenged with H5N1 at 6 weeks of age (Ferreira et al., 2014).
- Efficacy: Two rNDV-H5 administrations conferred a good level of protection after challenge, although only a cellular H5-specific response could be detected. Interestingly, a single administration of rNDV-H5 gave the same level of protection as the double administration but without any detectable H5-specific immune response (Ferreira et al., 2014).
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| References |
Ferreira et al., 2014: Ferreira HL, Rauw F, Pirlot JF, Reynard F, van den Berg T, Bublot M, Lambrecht B. Comparison of single 1-day-old chick vaccination using a Newcastle disease virus vector with a prime/boost vaccination scheme against a highly pathogenic avian influenza H5N1 challenge. Avian pathology : journal of the W.V.P.A. 2014; 43(1); 68-77. [PubMed: 24320551].
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