• Vaccine Name: ChAd63 -PvTRAP (chimpanzee adenovirus vaccine vector)
• Target Pathogen: malaria
• Type: Recombinant vector vaccine
• Status: Licensed
• Host Species for Licensed Use: Baboon
• Vector: simian adenovirus ChAd63 vaccine vector
  • Vector name: simian adenovirus ChAd63 vaccine vector
  • VO vector ID: VO_0001047
• Preparation: Recombinant ChAd63 and MVA vectors expressing P. vivax TRAP (PvTRAP) (Bauza et al., 2014).
• Immunization Route: Intramuscular injection (i.m.)

Mouse Response

• Vaccination Protocol: Mice were primed with simian adenoviral vector 63 (ChAd63) encoding PvTRAP at a dose of 1 × 108 infectious units (IU) and 8 weeks later boosted with modified vaccinia virus strain Ankara (MVA) carrying the same transgene at a concentration of 1 × 107 PFU per ml, unless otherwise stated. All viral vector vaccines were administered intramuscularly in endotoxin-free PBS (Bauza et al., 2014).
• Vaccine Immune Response Type: VO_0003057
• Challenge Protocol: Wild-type and transgenic parasites used to challenge mice were fed on infected TO mice, and then were released on to the vaccinated mice (Bauza et al., 2014).
• Efficacy: Using this model, we found that both CD8+ T cells and antibodies mediated protection against malaria using virus-vectored vaccines (Bauza et al., 2014).