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Vaccine Detail
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rMVA-CCHF |
| Vaccine Information |
- Vaccine Name: rMVA-CCHF
- Target Pathogen: Crimean-Congo Haemorrhagic Fever (CCHF)
- Vaccine Ontology ID: VO_0004665
- Type: Recombinant vector vaccine
- Status: Research
- Host Species for Licensed Use: Baboon
- Vector:
- Preparation: Modified Vaccinia virus Ankara was used to develop a recombinant candidate vaccine expressing the CCHF virus glycoproteins (Buttigieg et al., 2014).
- Immunization Route: Intramuscular injection (i.m.)
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| Host Response |
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Mouse Response
- Vaccine Immune Response Type: VO_0003057
- Efficacy: This vaccine protected all recipient animals from lethal disease in a challenge model adapted to represent infection via a tick bite (Buttigieg et al., 2014).
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| References |
Buttigieg et al., 2014: Buttigieg KR, Dowall SD, Findlay-Wilson S, Miloszewska A, Rayner E, Hewson R, Carroll MW. A novel vaccine against Crimean-Congo Haemorrhagic Fever protects 100% of animals against lethal challenge in a mouse model. PloS one. 2014; 9(3); e91516. [PubMed: 24621656].
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