• Vaccine Name: rVSVΔG-ANDV-GPC
• Target Pathogen: Hantavirus
• Target Disease: Hantavirus Pulmonary Syndrome
• Vaccine Ontology ID: VO_0004662
• Type: Recombinant vector vaccine
• Status: Research
• Host Species for Licensed Use: Baboon
• Vector:
  • Vector name:
  • VO vector ID: VO_0001025
• Immunization Route: Intramuscular injection (i.m.)

Hamster Response

• Vaccination Protocol: Syrian hamsters were immunized with a single injection of VSVΔG/ANDVGPC (Brown et al., 2011).
• Vaccine Immune Response Type: VO_0000287
• Challenge Protocol: After immunization, the hamsters were challenged at 28, 14, 7, or 3 days postimmunization with a lethal dose of ANDV (Brown et al., 2011).
• Efficacy: The hamsters were fully protected against the disease; however, the mechanism of protection seems to differ depending on when the immunization occurs. Administration of the vaccine at 7 or 3 days before challenge also resulted in full protection but with no specific neutralizing humoral immune response, suggesting a possible role of innate responses in protection against challenge virus replication. Administration of the vaccine 24 h postchallenge was successful in protecting 90% of hamsters and again suggested the induction of a potent antiviral state by the recombinant vector as a potential mechanism (Brown et al., 2011).