• Vaccine Name: rDEV-us78HA
• Target Pathogen: Influenza virus
• Target Disease: Influenza (flu)
• Vaccine Ontology ID: VO_0004658
• Type: Recombinant vector vaccine
• Status: Research
• Host Species for Licensed Use: Baboon
• Vector: duck enteritis virus vector
  • Vector name: duck enteritis virus vector
  • VO vector ID: VO_0001072
• Preparation: rDEV-ul41HA and rDEV-us78HA, in which the hemagglutinin (HA) gene of the H5N1 virus A/duck/Anhui/1/06 was inserted and stably maintained within the ul41 gene or between the us7 and us8 genes of the DEV genome (Liu et al., 2011).
• Immunization Route: Intramuscular injection (i.m.)

Ducks Response

• Vaccination Protocol: Ducks were inoculated intramuscularly with 0.1 ml of serum-free minimum essential medium diluted virus (Liu et al., 2011).
• Vaccine Immune Response Type: VO_0000287
• Challenge Protocol: The ducks were challenged with lethal DEV or H5N1 AIV at different time points postvaccination (p.v.) (Liu et al., 2011).
• Efficacy: All of the ducks in the groups inoculated with DEV and rDEV-us78HA remained healthy during the 2-week observation period. These results indicate that the recombinant viruses bearing the H5 HA gene insertion have immunogenicity similar to that of the DEV vaccine strain and induced protective immunity against lethal DEV challenge in as little as 3 days post vaccination (Liu et al., 2011).