• Vaccine Name: BDES-PfCSP (baculovirus dual expression system)
• Target Pathogen: malaria
• Type: Recombinant vector vaccine
• Status: Licensed
• Host Species for Licensed Use: Baboon
• Vector:
  • Vector name:
  • VO vector ID: VO_0001084
• Preparation: BDES-based Plasmodium falciparum circumsporozoite protein vaccines (BDES-PfCSP) (Iyori et al., 2013).
• Immunization Route: Intramuscular injection (i.m.)

Mouse Response

• Vaccination Protocol: Mice were immunized intramuscularly three times at 3-week intervals with 10^8 plaque forming units (PFU) of BDES-PfCSP, AcNPV-Dual-PbCSP or wild-type AcNPV (AcNPV-WT). A different group of mice were immunized twice at 3-week intervals with 10^10 VP of the Adeno-COE/1-373 vaccine (Iyori et al., 2013).
• Vaccine Immune Response Type: VO_0003057
• Challenge Protocol: Two weeks after the third immunization, the mice were challenged by blood feeding with parasite-infected mosquitoes. For the challenge infections (via natural biting), three to seven mosquitoes were allowed to feed on the abdomen of each mouse for 20 minutes (Iyori et al., 2013).
• Efficacy: Immunization of mice with BDES-PfCSP induced Th1/Th2-mixed type immune responses with high PfCSP-specific antibody (Ab) titers, and provided significant protection against challenge from the bites of mosquitoes infected with a transgenic P. berghei line expressing PfCSP (Iyori et al., 2013).