|
|
Vaccine Detail
|
AcHERV-sH1N1-HA |
| Vaccine Information |
- Vaccine Name: AcHERV-sH1N1-HA
- Target Pathogen: Influenza virus
- Target Disease: Influenza (flu)
- Vaccine Ontology ID: VO_0004653
- Type: Recombinant vector vaccine
- Status: Research
- Host Species for Licensed Use: Baboon
- HA
gene engineering:
- Type: Recombinant vector construction
- Description: This gene was inserted to a baculovirus vaccine vector (Choi et al., 2013).
- Detailed Gene Information: Click Here.
- Vector:
- Preparation: Human endogenous retrovirus (HERV) envelope-coated, nonreplicable, baculovirus-based HA vaccine against swine influenza A/California/04/2009(H1N1) hemagglutin (HA) (AcHERV-sH1N1-HA) (Choi et al., 2013).
- Immunization Route: Intramuscular injection (i.m.)
|
| Host Response |
|
Mouse Response
- Vaccination Protocol: Mice were intramuscularly administered AcHERV-sH1N1-HA or the commercial vaccine and subsequently given two booster injections (Choi et al., 2013).
- Vaccine Immune Response Type: VO_0003057
- Efficacy: After challenge with 10-times the median lethal dose (MLD50) of sH1N1 virus, 100% of BALB/c mice immunized with the commercial vaccine or AcHERV-sH1N1-HA survived. In contrast, C57BL/6 mice immunized with AcHERV-sH1N1-HA or the commercial vaccine showed 60% and 70% survival respectively, after challenge with sH1N1 virus (Choi et al., 2013).
|
| References |
Choi et al., 2013: Choi JY, Gwon YD, Kim JK, Cho YD, Heo YK, Cho HS, Choi TJ, Poo HR, Oh YK, Kim YB. Protective efficacy of a human endogenous retrovirus envelope-coated, nonreplicable, baculovirus-based hemagglutin vaccine against pandemic influenza H1N1 2009. PloS one. 2013; 8(11); e80762. [PubMed: 24260476].
|
|
