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Vaccine Detail

E. coli-CPPs (Edwardsiella tarda)
Vaccine Information
  • Vaccine Name: E. coli-CPPs (Edwardsiella tarda)
  • Target Pathogen: Edwardsiella tarda
  • Vaccine Ontology ID: VO_0004640
  • Type: Recombinant vector vaccine
  • Status: Research
  • Host Species for Licensed Use: Baboon
  • Vector:
  • Preparation: GFP-TAT synthesis circuit was combined with an in vivo inducible lysis circuit PviuA-E in E. coli to form an integrated antigen delivery system (Ma et al., 2014).
  • Immunization Route: Intramuscular injection (i.m.)
Host Response

Fish Response

  • Vaccine Immune Response Type: VO_0003057
  • Challenge Protocol: Hosts were challenged with E. tarda EIB202 (Ma et al., 2014).
  • Efficacy: This E. coli vector vaccine presented superior immune protection under the challenge with E. tarda EIB202, suggesting that the novel antigen delivery system had great potential in bacterial vector vaccine applications (Ma et al., 2014).
References
Ma et al., 2014: Ma J, Xu J, Guan L, Hu T, Liu Q, Xiao J, Zhang Y. Cell-penetrating peptides mediated protein cross-membrane delivery and its use in bacterial vector vaccine. Fish & shellfish immunology. 2014; 39(1); 8-16. [PubMed: 24746937].