• Vaccine Name: rHVT-H5 (clade 2.2 H5N1 HPAIV)
• Target Pathogen: Influenza virus
• Target Disease: Influenza (flu)
• Vaccine Ontology ID: VO_0004634
• Type: Recombinant vector vaccine
• Status: Research
• Host Species for Licensed Use: Baboon
• Vector: herpesvirus of turkey vaccine vector
  • Vector name: herpesvirus of turkey vaccine vector
  • VO vector ID: VO_0001067
• Immunization Route: Intramuscular injection (i.m.)

Chicken Response

• Vaccination Protocol: Birds carrying MDAs against both HVT and Asian H5N1 HPAIV were vaccinated on the first day of age with rHVT-H5, with or without boosting vaccination by an inactivated vaccine after 10 days (Rauw et al., 2012).
• Vaccine Immune Response Type: VO_0000287
• Challenge Protocol: The different groups were challenged with two antigenically highly divergent Egyptian dade 2.2.1 H5N1 HPAIVs at 4 wk of age (Rauw et al., 2012).
• Efficacy: Protection against challenge was compared with unvaccinated birds or vaccinated birds without MDAs. Between 70% and 90% clinical protection could be observed in the vaccinated groups possessing MDAs, indicating no or very low interference of MDAs with vaccination (Rauw et al., 2012).