• Vaccine Name: rHVT-H5
• Target Pathogen: Influenza virus
• Target Disease: Influenza (flu)
• Vaccine Ontology ID: VO_0004633
• Type: Recombinant vector vaccine
• Status: Research
• Host Species for Licensed Use: Chicken
• Vector:
  • Vector name:
  • VO vector ID: VO_0001067
• Preparation: A recombinant turkey herpesvirus (rHVT)-AI vaccine, rHVT-H5, was used to express the HA gene of a highly pathogenic avian influenza (HPAI) H5N1 clade 2.2 A/Swan/Hungary/499/ 2006 strain inserted into FC-126 strain of HVT vector (Soejoedono et al., 2012).
• Immunization Route: Intramuscular injection (i.m.)

Chicken Response

• Vaccine Immune Response Type: VO_0003057
• Efficacy: Challenge was performed at 28 days of age using a different H5N1 isolate, clade 2.1.3 A/Ck/Purwakarta-Cilingga/142/10. Clinical protection was 95%, 75%, and 90% in Group 1, 2, and 3, respectively. Shedding of challenge virus was significantly lower in the vaccinated groups compared with controls in both experiments (Soejoedono et al., 2012).