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Vaccine Detail
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rAd-GP (Ebola virus) |
| Vaccine Information |
- Vaccine Name: rAd-GP (Ebola virus)
- Target Pathogen: Ebola virus
- Target Disease: Ebola hemorrhagic fever
- Vaccine Ontology ID: VO_0004631
- Type: Recombinant vector vaccine
- Status: Research
- Host Species for Licensed Use: Baboon
- GP from Zaire ebolavirus
gene engineering:
- Type: Recombinant protein preparation
- Description:
- Detailed Gene Information: Click Here.
- Vector: human adenovirus vaccine vector
- Preparation: (O'Brien et al., 2014)
- Immunization Route: Intramuscular injection (i.m.)
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| Host Response |
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Mouse Response
- Host Strain: IFNR(-/-) mice
- Vaccine Immune Response Type: VO_0003057
- Immune Response: the antibody response in IFNR(-/-) mice was similar to that observed in vaccinated wild-type mice (O'Brien et al., 2014).
- Efficacy: The recombinant vaccines elicited good levels of protection in the knock-out mouse (O'Brien et al., 2014).
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| References |
O'Brien et al., 2014: O'Brien LM, Stokes MG, Lonsdale SG, Maslowski DR, Smither SJ, Lever MS, Laws TR, Perkins SD. Vaccination with recombinant adenoviruses expressing Ebola virus glycoprotein elicits protection in the interferon alpha/beta receptor knock-out mouse. Virology. 2014; 452-453; 324-333. [PubMed: 24461913].
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