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Vaccine Detail
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L. T -PpSP15 |
| Vaccine Information |
- Vaccine Name: L. T -PpSP15
- Target Pathogen: Leishmania major
- Target Disease: Cutaneous leishmaniasis
- Vaccine Ontology ID: VO_0004627
- Type: Recombinant vector vaccine
- Status: Research
- Host Species for Licensed Use: Human
- Host Species as Laboratory Animal Model: mouse
- Antigen: CPA/CPB(Zahedifard et al., 2014)
- Vector: Leishmania tarentolae vaccine vector
- Immunization Route: Intramuscular injection (i.m.)
- Description: A Leishmania major recombinant vector vaccine that uses a Salmonella vector and CPA/CPB as antigen (Zahedifard et al., 2014).
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| Host Response |
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Mouse Response
- Vaccine Immune Response Type: VO_0003057
- Efficacy: In both susceptible BALB/c and resistant C57BL/6 mice, the strongest protective effect was observed when priming with PpSP15 DNA and boosting with PpSP15 DNA and live recombinant L. tarentolae stably expressing cysteine proteinase genes (Zahedifard et al., 2014).
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| References |
Zahedifard et al., 2014: Zahedifard F, Gholami E, Taheri T, Taslimi Y, Doustdari F, Seyed N, Torkashvand F, Meneses C, Papadopoulou B, Kamhawi S, Valenzuela JG, Rafati S. Enhanced protective efficacy of nonpathogenic recombinant leishmania tarentolae expressing cysteine proteinases combined with a sand fly salivary antigen. PLoS neglected tropical diseases. 2014; 8(3); e2751. [PubMed: 24675711].
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