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Vaccine Detail
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pCDH-nfa1 |
| Vaccine Information |
- Vaccine Name: pCDH-nfa1
- Target Pathogen: Naegleria fowleri
- Type: Recombinant vector vaccine
- Status: Research
- Host Species for Licensed Use: Baboon
- Vector:
- Preparation: A lentiviral vector (pCDH) expressing the nfa1 gene (Kim et al., 2013).
- Immunization Route: Intramuscular injection (i.m.)
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| Host Response |
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Mouse Response
- Vaccination Protocol: Mice were intranasally vaccinated with viral particles of a viral vector expressing the nfa1 gene (Kim et al., 2013).
- Vaccine Immune Response Type: VO_0003057
- Challenge Protocol: Vaccinated mice were challenged intranasally with 5 × 10^4 trophozoites of N. fowleri at 1 week after the last vaccination (Kim et al., 2013).
- Efficacy: The mice vaccinated with viral vector expressing the nfa1 gene also exhibited significantly higher survival rates (90%) after challenge with N. fowleri trophozoites. Finally, the nfa1 vaccination effectively induced protective immunity by humoral and cellular immune responses in N. fowleri-infected mice (Kim et al., 2013).
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| References |
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