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Vaccine Detail

rFPV-IBDV-VP2
Vaccine Information
  • Vaccine Name: rFPV-IBDV-VP2
  • Target Pathogen: Infectious Bursal Disease Virus (IBDV)
  • Target Disease: Infectious Bursal Disease
  • Vaccine Ontology ID: VO_0004625
  • Type: Recombinant vector vaccine
  • Status: Research
  • Host Species for Licensed Use: Chicken
  • VP2 gene engineering:
    • Type: Recombinant vector construction
    • Description: Marek's disease and Fowlpox viruses expressing the vvIBDV host-protective antigen VP2 (rMDV, rFPV) (Tsukamoto et al., 2000).
    • Detailed Gene Information: Click Here.
  • Vector:
  • Preparation: Marek's disease and Fowlpox viruses expressing the vvIBDV host-protective antigen VP2 (rMDV, rFPV) (Tsukamoto et al., 2000).
  • Immunization Route: Intramuscular injection (i.m.)
Host Response

Chicken Response

  • Vaccination Protocol: Chickens vaccinated with the rFPV or rMDV alone, or vaccinated simultaneously with both at their hatch (rMDV-rFPV(1d)) (Tsukamoto et al., 2000).
  • Vaccine Immune Response Type: VO_0003057
  • Efficacy: Most chickens were protected against developing clinical signs and mortality; however, only zero to 14% of the chickens were protected against gross lesions (Tsukamoto et al., 2000).
References
Tsukamoto et al., 2000: Tsukamoto K, Sato T, Saito S, Tanimura N, Hamazaki N, Mase M, Yamaguchi S. Dual-viral vector approach induced strong and long-lasting protective immunity against very virulent infectious bursal disease virus. Virology. 2000; 269(2); 257-267. [PubMed: 10753704].