• Vaccine Name: FPV-LT vaccine
• Target Pathogen: infectious laryngotracheitis virus
• Vaccine Ontology ID: VO_0004624
• Type: Recombinant vector vaccine
• Status: Research
• Host Species for Licensed Use: Chicken
• Vector: fowlpox virus vaccine vector
  • Vector name: fowlpox virus vaccine vector
  • VO vector ID: VO_0001040
• Preparation: Viral vector vaccines using fowl poxvirus (FPV) and herpesvirus of turkey (HVT) as vectors and carrying infectious laryngotracheitis virus (ILTV) genes (Vagnozzi et al., 2012).
• Immunization Route: Intramuscular injection (i.m.)

Chicken Response

• Vaccination Protocol: Live-attenuated ILT vaccines were administered as a full dose, and the recombinant vectored vaccines were administered as a half dose to mimic broiler industry practices. The viral vector vaccines were administered in ovo and subcutaneously at hatch while the live-attenuated vaccines, CEO and TCO, were administered via eye drop at 14 days of age (Vagnozzi et al., 2012).
• Vaccine Immune Response Type: VO_0003057
• Challenge Protocol: All chickens were weighed before challenge. With the exception of the NVx-NCh group, all chickens were challenged at 35 days of age with the virulent ILTV field isolate 63140 administered in a total volume of 200 µl, 100 µl intratracheally and 50 µl via eye drop per eye (Vagnozzi et al., 2012).
• Efficacy: The FPV-LT vaccine mitigated clinical signs more effectively when administered subcutaneously than in ovo (Vagnozzi et al., 2012).