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Vaccine Detail

GM-CSF, IL-12 and GM-CSF+IL-12 genetically modified tumor cell vaccine

Vaccine Information

Vaccine Name: GM-CSF, IL-12 and GM-CSF+IL-12 genetically modified tumor cell vaccine
Target Pathogen: Cancer
Target Disease: Cancer
Vaccine Ontology ID: VO_0007478
Type: genetically modified tumor cell vaccines
Status: Clinical trial
Preparation: Used C57BL/6 mice and irradiated B16 tumor cells expressing granulocyte and macrophage colony-stimulating factor (GM-CSF), interleukin-12 (IL-12) or both. Tumor was transplanted by the injection of wild-type B16 cells. Tumor growth and survival were measured to evaluate the efficacy of vaccination. Specific humoral response and immunoglobulin G (IgG) switch were evaluated measuring total IgG and IgG1 and IgG2a subtypes against tumor membrane proteins of B16 cells (Miguel et al., 2013).
Immunization Route: Intramuscular injection (i.m.)

Host Response

References

Miguel et al., 2013: Miguel A, Herrero MJ, Sendra L, Botella R, AlgÃ¡s R, SÃ¡nchez M, AliÃ±o SF. Comparative antitumor effect among GM-CSF, IL-12 and GM-CSF+IL-12 genetically modified tumor cell vaccines. Cancer gene therapy. 2013; 20(10); 576-581. [PubMed: 23969885].