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Vaccine Detail
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DNA Vaccine encoding p42.3 |
| Vaccine Information |
- Vaccine Name: DNA Vaccine encoding p42.3
- Target Pathogen: Cancer
- Target Disease: Cancer
- Vaccine Ontology ID: VO_0007600
- Type: DNA vaccine
- Status: Clinical trial
- Antigen: p42.3
- Preparation: We immunized C57BL/6 mice with a DNA vaccine encoding p42.3. We used intramuscular injection with electroporation, either before or after challenge with tumor B16F10 cells. Vaccination with pcDNA3-p42.3 induced some degree of antitumor effect both therapeutically and prophylactically, as evaluated by the inhibition of tumor growth and decrease in tumor weight (Liu et al., 2013).
- Immunization Route: Intramuscular injection (i.m.)
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| Host Response |
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Mouse Response
- Vaccine Immune Response Type: VO_0003057
- Immune Response: High level of specific cytotoxic activity against the p42.3 protein in vivo and had activated CD8 T cells that secreted IFN-γ, perforin, and granzyme B in response to stimulation with the antigen in vitro (Liu et al., 2013).
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| References |
Liu et al., 2013: Liu H, Geng S, Feng C, Xie X, Wu B, Chen X, Zou Q, Wang S, Cui J, Xing R, Li W, Lu Y, Wang B. A DNA vaccine targeting p42.3 induces protective antitumor immunity via eliciting cytotoxic CD8+T lymphocytes in a murine melanoma model. Human vaccines & immunotherapeutics. 2013; 9(10); 2196-2202. [PubMed: 24051432].
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