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Vaccine Detail
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long-peptide vaccine and mAb |
| Vaccine Information |
- Vaccine Name: long-peptide vaccine and mAb
- Target Pathogen: Cancer
- Target Disease: Cancer
- Vaccine Ontology ID: VO_0007633
- Type: monoclonal antibody and peptide vaccine
- Status: Research
- Antigen: tyrosinase-related protein (TRP)-1 surface Ag, self-differentiation Ags gp100 and TRP-2 (Ly et al., 2013)
- Immunization Route: Intramuscular injection (i.m.)
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| Host Response |
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Mouse Response
- Vaccine Immune Response Type: VO_0003057
- Immune Response: Vaccine formulations with synthetic long peptides failed to elicit strong CD8 T cell responses to self-differentiation Ags gp100 and TRP-2, whereas altered peptide sequences recruited gp100-specific CD8 T cells from the endogenous repertoire with frequencies of 40%(Ly et al., 2013)
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| References |
Ly et al., 2013: Ly LV, Sluijter M, van der Burg SH, Jager MJ, van Hall T. Effective cooperation of monoclonal antibody and peptide vaccine for the treatment of mouse melanoma. Journal of immunology (Baltimore, Md. : 1950). 2013; 190(1); 489-496. [PubMed: 23203930].
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