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Vaccine Detail
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mCRT-vGPCR-coated whole-cell vaccine |
| Vaccine Information |
- Vaccine Name: mCRT-vGPCR-coated whole-cell vaccine
- Target Pathogen: Cancer
- Target Disease: Cancer
- Vaccine Ontology ID: VO_0007639
- Type: Whole cell
- Status: Research
- Immunization Route: Intramuscular injection (i.m.)
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| Host Response |
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Mouse Response
- Vaccine Immune Response Type: VO_0003057
- Immune Response: The specific antitumour immune response was observed when the mCRT-vGPCR-coated B16-F1 cells were used as a whole-cell tumour vaccine to immune mice, which included significantly enhanced cytotoxic T lymphocyte (CTL) activities and increased the number of IFN-γ-producing T cells(Wu et al., 2013)
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| References |
Wu et al., 2013: Wu H, Han Y, Qin Y, Cao C, Xia Y, Liu C, Wang Y. Whole-cell vaccine coated with recombinant calreticulin enhances activation of dendritic cells and induces tumour-specific immune responses. Oncology reports. 2013; 29(2); 529-534. [PubMed: 23166014].
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