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Vaccine Detail
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intralesional bacile Calmette-Guérin (BCG), DTIC, vincristine |
| Vaccine Information |
- Vaccine Name: intralesional bacile Calmette-Guérin (BCG), DTIC, vincristine
- Target Pathogen: Cancer
- Target Disease: Cancer
- Vaccine Ontology ID: VO_0007625
- Type: chemotherapy drugs
- Status: Research
- Preparation: This immunization protocol consisted of the intradermal inoculation of 2 times 10(7) irradiated allogeneic melanoma cells admixed with 50 mug of percutaneous BCG (Currie and McElwain, 1975).
- Immunization Route: Intramuscular injection (i.m.)
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| Host Response |
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Human Response
- Vaccine Immune Response Type: VO_0003057
- Description: This method of immunization induced a significant but transient fall in the specific inhibitory effects of the sera on tumour directed cytotoxic activity of the patients' lymphocytes. BCG alone had no detectable effect on the serum inhibitory activity level, whereas the inclusion of tumour cells in the mixture led to a prompt fall (Currie and McElwain, 1975).
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| References |
Currie and McElwain, 1975: Currie GA, McElwain TJ. Active immunotherapy as an adjunct to chemotherapy in the treatment of disseminated malignant melanoma: a pilot study. British journal of cancer. 1975; 31(2); 143-156. [PubMed: 1164466].
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