• Vaccine Name: intralesional bacile Calmette-Guérin (BCG)
• Target Pathogen: Cancer
• Target Disease: Cancer
• Vaccine Ontology ID: VO_0007624
• Type: Live, attenuated vaccine
• Status: Research
• Antigen: melanoma antigens
• Immunization Route: Intramuscular injection (i.m.)
• Description: BCG activates both specific and nonspecific immune responses. Thus, in vitro parameters of cellular immunity, including migration inhibitory factor production and inhibition of leukocyte migration, are affected by intralesional BCG, and some, particularly the lymphocyte stimulation and rosette test, seem to correlate with the clinical response of the patients (Lieberman et al., 1975).

Human Response

• Vaccine Immune Response Type: VO_0003057
• Immune Response: Two of four responders showed inhibition of leukocyte migration to melanoma antigens before BCG, and two of four responders were positive after BCG. There was a marked increase in active rosette forming cells in all responders and in one of the two nonresponders (Lieberman et al., 1975).