• Vaccine Name: Bacillus Calmette-Guerin (BCG), C. parvum
• Target Pathogen: Cancer
• Target Disease: Cancer
• Vaccine Ontology ID: VO_0007583
• Type: Live, attenuated vaccine
• Status: Research
• Immunization Route: Intramuscular injection (i.m.)

Human Response

• Vaccine Immune Response Type: VO_0003057
• Immune Response: total white count tended to increase but little change was seen in lymphocyte and monocyte counts. Serum IgG increased after BCG BUT NOT WITH C. parvum, serum IgA and IgM did not alter. The 'E' rosette % did show some increase mainly after C. parvum, and 'B' lymphoid cells (sIg staining) increased slightly after BCG; the 'EA' rosette % fell following C. parvum but not after BCG. Lymphocyte PHA blastogenesis increased after immunisation, particularly with BCG. Non-specific lymphocytotoxicity (51 Cr Chang target) demonstrated dramatic increases for 'non T' and 'K' cell function and a smaller increase in 'T' cell cytotoxicity following immunization (Thatcher and Crowther, 1977).