VIOLIN: Vaccine Investigation and Online Information Network

Vaccine Detail

gp100 Vaccine

Vaccine Information

Vaccine Name: gp100 Vaccine
Target Pathogen: Cancer
Target Disease: Cancer
Vaccine Ontology ID: VO_0007607
Type: synthetic peptide
Status: Research
Antigen: gp100
Immunization Route: Intramuscular injection (i.m.)
Description: Synthetic peptide vaccines based on the genes encoding cancer antigens hold promise for the development of novel cancer immunotherapies (Rosenberg et al., 1998).

Host Response

Human Response

Vaccine Immune Response Type: VO_0003057
Immune Response: These experiments thus demonstrated that patients immunized with the g209-2M synthetic peptide in IFA consistently developed high levels of circulating immune precursors reactive with the native g209–217 peptide and with tumor (Rosenberg et al., 1998).

References

Rosenberg et al., 1998: Rosenberg SA, Yang JC, Schwartzentruber DJ, Hwu P, Marincola FM, Topalian SL, Restifo NP, Dudley ME, Schwarz SL, Spiess PJ, Wunderlich JR, Parkhurst MR, Kawakami Y, Seipp CA, Einhorn JH, White DE. Immunologic and therapeutic evaluation of a synthetic peptide vaccine for the treatment of patients with metastatic melanoma. Nature medicine. 1998; 4(3); 321-327. [PubMed: 9500606].