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Vaccine Detail
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HCA587 protein vaccine |
| Vaccine Information |
- Vaccine Name: HCA587 protein vaccine
- Target Pathogen: Cancer
- Target Disease: Cancer
- Product Name: Chen et al., 2012
- Vaccine Ontology ID: VO_0007612
- Type: Live, attenuated vaccine
- Status: Research
- Antigen: CpG-containing oligodeoxynucleotides (CpG ODN) and ISCOM(Chen et al., 2012)
- Immunization Route: Intramuscular injection (i.m.)
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| Host Response |
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Mouse Response
- Vaccine Immune Response Type: VO_0003057
- Immune Response: The depletion of CD4+ T cells abrogated the antitumor effect, while CD8+ T cells depletion showed no influence on the efficacy of the HCA587 protein vaccine. The tumor-free mice showed high percentage of IFN-γ-producing splenocytes compared with the tumor-bearing mice, and the mice with smaller tumors tended to have more such cells than the mice with larger tumor volume.(Chen et al., 2012)
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| References |
Chen et al., 2012: Chen J, Zhang L, Wen W, Hao J, Zeng P, Qian X, Zhang Y, Yin Y. Induction of HCA587-specific antitumor immunity with HCA587 protein formulated with CpG and ISCOM in mice. PloS one. 2012; 7(10); e47219. [PubMed: 23071764].
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