• Vaccine Name: Chinese S. japonicum M6-Sj-F1 Vaccine Vector
• Target Pathogen: Schistosoma japonicum
• Target Disease: Schistosomiasis
• Type: Recombinant vector vaccine
• Status: Research
• Antigen: The Sj-F1 antigen of S. japonicum (Wang et al., 2013).
• Immunization Route: intranasal immunization
• Description: Because chemotherapy is currently the main effective method to treat schistosomiasis, but it doesn't prevent reinfection, there has been a need to create a vaccine that can safely express the pathogenic antigen and elicit protection against the disease. This vectored vaccine has been shown to partially protect laboratory mice from S. japonicum challenge, making it a good candidate for schistosomiasis prevention (Wang et al., 2013).

Mouse Response

• Vaccine Immune Response Type: VO_0000287
• Immune Response: The mice inoculated with the vaccine showed strong serum IgG, serum IgA, and saliva IgA antibodies against the antigen Sj-F1 (Wang et al., 2013).
• Challenge Protocol: The mice were challenged with the cercariae (parasitic larva) of S. japonicum (Wang et al., 2013).
• Efficacy: The mice immunized with the vaccine showed "significant protection" including a 21.45% reduction in the number of parasitic worms present and a 34.77% reduction in the number of eggs (Wang et al., 2013).
• Description: The protection received shows that the S. gordonii vector expressing S. japonicum is highly immunogenic and has potential to become a safe, effective vaccine against schistosomiasis (Wang et al., 2013).