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Vaccine Detail
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P. knowlesi DNA vaccine encoding PkCSP, PkSSP2, PkAMA1, and PkMSP1p42 |
| Vaccine Information |
- Vaccine Name: P. knowlesi DNA vaccine encoding PkCSP, PkSSP2, PkAMA1, and PkMSP1p42
- Target Pathogen: Plasmodium spp.
- Target Disease: Malaria
- Vaccine Ontology ID: VO_0004595
- Type: DNA vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Rhesus monkeys
- AMA1 from P. knowlesi
gene engineering:
- Type: DNA vaccine construction
- Description:
- Detailed Gene Information: Click Here.
- CSP from P. knowlesi
gene engineering:
- Type: DNA vaccine construction
- Description:
- Detailed Gene Information: Click Here.
- MSP1 from P. knowlesi
gene engineering:
- Type: DNA vaccine construction
- Description:
- Detailed Gene Information: Click Here.
- SSP2 from P. knowlesi
gene engineering:
- Type: DNA vaccine construction
- Description:
- Detailed Gene Information: Click Here.
- DNA vaccine plasmid: pVR1020 DNA vaccine plasmid
- Immunization Route: Intramuscular injection (i.m.)
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| Host Response |
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Monkey Response
- Vaccine Immune Response Type: VO_0003057
- Challenge Protocol: 100 sporozoites were injected into the saphenous vein. Beginning on day 6 after challenge peripheral thick and thin blood films were examined to determine parasitemia. (Rogers et al., 2001)
- Efficacy: Following challenge with 100 P. knowlesi sporozoites, 1 of 12 experimental monkeys was completely protected and the mean parasitemia in the remaining monkeys was significantly lower than that in 4 control monkeys (Rogers et al., 2001).
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| References |
Rogers et al., 2001: Rogers WO, Baird JK, Kumar A, Tine JA, Weiss W, Aguiar JC, Gowda K, Gwadz R, Kumar S, Gold M, Hoffman SL. Multistage multiantigen heterologous prime boost vaccine for Plasmodium knowlesi malaria provides partial protection in rhesus macaques. Infection and immunity. 2001; 69(9); 5565-5572. [PubMed: 11500430].
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