• Vaccine Name: Infectious Bursal Disease Virus DNA Vaccine expressing VP2
• Target Pathogen: Infectious Bursal Disease Virus (IBDV)
• Target Disease: Infectious Bursal Disease
• Vaccine Ontology ID: VO_0004585
• Type: DNA vaccine
• Status: Research
• VP2 gene engineering:
  • Type: DNA vaccine construction
  • Description:
  • Detailed Gene Information: Click Here.
• DNA vaccine plasmid:
  • DNA vaccine plasmid name:
  • DNA vaccine plasmid VO ID: VO_0000262
• Immunization Route: Intramuscular injection (i.m.)

Chicken Response

• Vaccination Protocol: The birds were immunized intramuscularly with 50 μg plasmid DNA in the quadricep muscle of the hind limb (Kumar et al., 2009).
• Vaccine Immune Response Type: VO_0003057
• Immune Response: Birds immunized with pibdVP2-IRES-chiIL-2 plasmid at 21 days post-challenge showed the highest antibody titer. In addition, blood analysis showed a proliferation of CD4-positive cells in the group vaccinated with pibdVP2-IRES-chiIL-2 (Kumar et al., 2009).
• Challenge Protocol: All vaccinated birds and the unvaccinated control birds were challenged with 10^5 ELD50 (50% embryo lethal dose) virulent IBDV (strain KT1/99) through the intrabursal and intraocular routes at 21 days post-immunization (Kumar et al., 2009).
• Efficacy: Birds vaccinated with the pibdVP2-IRES-chiIL-2 plasmid showed an 80% protection efficacy (Kumar et al., 2009).