• Vaccine Name: IBV DNA vaccine pVAX-S1 with GM-CSF adjuvant
• Target Pathogen: Infectious Bronchitis Virus (IBV)
• Target Disease: Infectious Bronchitis
• Vaccine Ontology ID: VO_0004582
• Type: DNA vaccine
• Status: Research
• Host Species as Laboratory Animal Model: Chickens
• S1 gene engineering:
  • Type: DNA vaccine construction
  • Description:
  • Detailed Gene Information: Click Here.
• DNA vaccine plasmid:
  • DNA vaccine plasmid name:
  • DNA vaccine plasmid VO ID: VO_0000024
• Immunization Route: Intramuscular injection (i.m.)

Mouse Response

• Vaccine Immune Response Type: VO_0003057
• Immune Response: Vaccination with pVAX-S1 plus pVAX-chGM-CSF induced a level of anti-IBV antibodies that was significantly higher than in animals receiving pVAX-S1 alone (P < 0.05) beginning on the seventh day after booster vaccination (Tan et al., 2009).
• Efficacy: PBS and pVAX1 immunized groups had 0% protection efficacy. The protection efficacy in the group vaccinated with the pVAX-S1 plus pVAX- chGM-CSF was 86.7%, whereas for the group vaccinated with pVAX-S1 alone, it was 73.3%. These results suggest that chGM-CSF, used as a molecular adjuvant, can improve the protection efficacy of an IBV S1 protein DNA vaccine (Tan et al., 2009).