|
|
Vaccine Detail
|
IBV DNA vaccine pVAX1-N |
| Vaccine Information |
- Vaccine Name: IBV DNA vaccine pVAX1-N
- Target Pathogen: Infectious Bronchitis Virus (IBV)
- Target Disease: Infectious Bronchitis
- Vaccine Ontology ID: VO_0004581
- Type: DNA vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Chickens
- N protein
gene engineering:
- Type: DNA vaccine construction
- Description:
- Detailed Gene Information: Click Here.
- DNA vaccine plasmid:
- DNA vaccine plasmid name:
- DNA vaccine plasmid VO ID: VO_0000024
- Immunization Route: Intramuscular injection (i.m.)
|
| Host Response |
|
Chicken Response
- Vaccine Immune Response Type: VO_0003057
- Efficacy: Priming with a DNA vaccine encoding nucleocapsid protein (pVAX1-N) and boosting with the inactivated IBV vaccine provided up to 86.7% rate of immune protection, compared to the lack of protection seen in the PBS-immunized group, where the death rate was 66.7% (Guo et al., 2010).
|
| References |
Guo et al., 2010: Guo Z, Wang H, Yang T, Wang X, Lu D, Li Y, Zhang Y. Priming with a DNA vaccine and boosting with an inactivated vaccine enhance the immune response against infectious bronchitis virus. Journal of virological methods. 2010; 167(1); 84-89. [PubMed: 20307574].
|
|
