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Vaccine Detail
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RHDV DNA vaccine pcDNA-VP60 |
| Vaccine Information |
- Vaccine Name: RHDV DNA vaccine pcDNA-VP60
- Target Pathogen: Rabbit hemorrhagic disease virus
- Target Disease: Rabbit hemorrhagic disease
- Vaccine Ontology ID: VO_0004577
- Type: DNA vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Rabbits
- ORF1
gene engineering:
- Type: DNA vaccine construction
- Description:
- Detailed Gene Information: Click Here.
- DNA vaccine plasmid: pcDNA3.1 DNA vaccine plasmid
- Immunization Route: Intramuscular injection (i.m.)
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| Host Response |
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Rabbit Response
- Vaccine Immune Response Type: VO_0003057
- Immune Response: In all cases, the rabbits immunized with pcDNA-VP60 developed high level of RHDV-specific antibodies and cellular immune response (Yuan et al., 2013).
- Efficacy: The rabbits inoculated with PBS and pcDNA3.1(+) were not protected from the RHDV challenge and developed high fever and oronasal hemorrhage, and died within two days after challenge as a consequence of the viral infection. All pcDNA-VP60 and RHDV inactive vaccine vaccinated rabbits survived (Yuan et al., 2013).
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| References |
Yuan et al., 2013: Yuan D, Qu L, Liu J, Guo D, Jiang Q, Lin H, Si C. DNA vaccination with a gene encoding VP60 elicited protective immunity against rabbit hemorrhagic disease virus. Veterinary microbiology. 2013; 164(1-2); 1-8. [PubMed: 23419819].
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