• Vaccine Name: BRSV DNA vaccine VCL-Fb
• Target Pathogen: Bovine Respiratory Syncytial Virus
• Target Disease: Respiratory Disease
• Vaccine Ontology ID: VO_0004574
• Type: DNA vaccine
• Status: Research
• Host Species as Laboratory Animal Model: Calves
• F gene engineering:
  • Type: DNA vaccine construction
  • Description:
  • Detailed Gene Information: Click Here.
• DNA vaccine plasmid:
  • DNA vaccine plasmid name:
  • DNA vaccine plasmid VO ID: VO_0000999
• Immunization Route: Intramuscular injection (i.m.)

Cattle Response

• Vaccine Immune Response Type: VO_0003057
• Immune Response: Seven days after BRSV challenge, BRSV-specific serum IgA titres in calves vaccinated i.m. with VCL-Fb were significantly greater than those in calves vaccinated by the i.d. route (P < 0.05) (Taylor et al., 2005).
• Efficacy: Vaccination with DNA encoding the BRSV F protein can induce a significant reduction in BRSV excretion in young calves. At slaughter, 7 days after challenge, BRSV was isolated from the lungs of three out of four calves vaccinated with control plasmid, two out of six calves vaccinated i.d. with VCL-Fb, but none of the calves vaccinated i.m. with VCL-Fb (Taylor et al., 2005).