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Vaccine Detail
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P. aeruginosa DNA vaccine pGACAG-PcrV |
| Vaccine Information |
- Vaccine Name: P. aeruginosa DNA vaccine pGACAG-PcrV
- Target Pathogen: Pseudomonas aeruginosa
- Target Disease: Pseudomonas aeruginosa infection
- Vaccine Ontology ID: VO_0004571
- Type: DNA vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Mouse
- PcrV
gene engineering:
- Type: DNA vaccine construction
- Description:
- Detailed Gene Information: Click Here.
- DNA vaccine plasmid:
- DNA vaccine plasmid name:
- DNA vaccine plasmid VO ID: VO_0000998
- Immunization Route: intramuscular electroporation
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| Host Response |
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Mouse Response
- Vaccine Immune Response Type: VO_0003057
- Efficacy: Monovalent DNA vaccination targeting PcrV could protect 80% of mice 4 days p.i. On the other hand, 70% of mice immunized with the control plasmid, PilA vaccine, or multivalent vaccine via GG were dead within 5 days p.i. (p < 0.01) (Saha et al., 2006).
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| References |
Saha et al., 2006: Saha S, Takeshita F, Sasaki S, Matsuda T, Tanaka T, Tozuka M, Takase K, Matsumoto T, Okuda K, Ishii N, Yamaguchi K, Klinman DM, Xin KQ, Okuda K. Multivalent DNA vaccine protects mice against pulmonary infection caused by Pseudomonas aeruginosa. Vaccine. 2006; 24(37-39); 6240-6249. [PubMed: 16806598].
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