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Vaccine Detail
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N. meningitidis DNA vaccine P3A |
| Vaccine Information |
- Vaccine Name: N. meningitidis DNA vaccine P3A
- Target Pathogen: Neisseria meningitidis
- Target Disease: Meningitis
- Vaccine Ontology ID: VO_0004569
- Type: DNA vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Mouse
- Antigen: a T-cell helper epitope and a peptide mimic of N. meningitidis serogroup C (Prinz et al., 2003)
- gp120
gene engineering:
- Type: DNA vaccine construction
- Description: The T-cell epitope used was from HIV gp120 (Prinz et al., 2003).
- Detailed Gene Information: Click Here.
- DNA vaccine plasmid: pcDNA3.1 DNA vaccine plasmid
- Immunization Route: Intramuscular injection (i.m.)
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| Host Response |
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Mouse Response
- Vaccine Immune Response Type: VO_0003057
- Immune Response: Mice immunized with P3A DNA produced an anti-MCPS IgM antibody response that was significantly higher (P < 0.05) than that of mice immunized with P3C DNA (negative control) (Prinz et al., 2003).
- Efficacy: Mice immunized with P3A DNA were protected against meningococcal infection, with 100% survival. Five of the six mice immunized with P3C DNA (negative control) died within 24 hr postchallenge (Prinz et al., 2003).
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| References |
Prinz et al., 2003: Prinz DM, Smithson SL, Kieber-Emmons T, Westerink MA. Induction of a protective capsular polysaccharide antibody response to a multiepitope DNA vaccine encoding a peptide mimic of meningococcal serogroup C capsular polysaccharide. Immunology. 2003; 110(2); 242-249. [PubMed: 14511238].
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