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Vaccine Detail
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Leptospira interrogans DNA vaccine pTARGET/ LigBrep |
| Vaccine Information |
- Vaccine Name: Leptospira interrogans DNA vaccine pTARGET/ LigBrep
- Target Pathogen: Leptospira spp.
- Target Disease: Leptospirosis
- Vaccine Ontology ID: VO_0004563
- Type: DNA vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Hamsters
- ligB
gene engineering:
- Type: DNA vaccine construction
- Description:
- Detailed Gene Information: Click Here.
- DNA vaccine plasmid:
- DNA vaccine plasmid name:
- DNA vaccine plasmid VO ID: VO_0000318
- Immunization Route: Intramuscular injection (i.m.)
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| Host Response |
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Hamster Response
- Vaccine Immune Response Type: VO_0003057
- Immune Response: The vaccine induced an IgG antibody response and, additionally, conferred sterilizing immunity in 80% of the surviving animals (Forster et al., 2013).
- Efficacy: Immunization with a DNA vaccine encoding LigBrep resulted in the survival of 5/8 (62.5%) hamsters against lethal infection (P < 0.05). None of the control hamsters or animals immunized with the other vaccine preparations survived (Forster et al., 2013).
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| References |
Forster et al., 2013: Forster KM, Hartwig DD, Seixas FK, Bacelo KL, Amaral M, Hartleben CP, Dellagostin OA. A Conserved Region of Leptospiral Immunoglobulin-Like A and B Proteins as a DNA Vaccine Elicits a Prophylactic Immune Response against Leptospirosis. Clinical and vaccine immunology : CVI. 2013; 20(5); 725-731. [PubMed: 23486420].
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