• Vaccine Name: Leptospira interrogans DNA vaccine ompL1-pcDNA3.1(+)
• Target Pathogen: Leptospira spp.
• Target Disease: Leptospirosis
• Vaccine Ontology ID: VO_0004562
• Type: DNA vaccine
• Status: Research
• Host Species as Laboratory Animal Model: Hamsters
• ompL1 gene engineering:
  • Type: DNA vaccine construction
  • Description:
  • Detailed Gene Information: Click Here.
• DNA vaccine plasmid:
  • DNA vaccine plasmid name:
  • DNA vaccine plasmid VO ID: VO_0000158
• Immunization Route: Intramuscular injection (i.m.)

Hamster Response

• Vaccine Immune Response Type: VO_0003057
• Efficacy: The vaccine was shown to confer the delay in the death time and reduced morbidity in the vaccinated animals when compared to animals immunized with the plasmid alone or PBS. Hamsters of group 2 (mock) and group 3 (positive leptospirosis) were all dead between days 5 and 6 post-challenge. For the vaccinated group, two hamsters were dead on day 9, one each died on days 11 and 18, respectively. Two hamsters survived the lethal Leptospira challenge until day 21 when they were sacrificed (Maneewatch et al., 2007).