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Vaccine Detail
E. tarda DNA vaccine pCE6 |
Vaccine Information |
- Vaccine Name: E. tarda DNA vaccine pCE6
- Target Pathogen: Edwardsiella tarda
- Vaccine Ontology ID: VO_0004557
- Type: DNA vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Japanese flounder
- Antigen: FliC-Eta6 fusion protein from E. tarda TX1 (Jiao et al., 2009)
- fliC
gene engineering:
- Type: DNA vaccine construction
- Description:
- Detailed Gene Information: Click Here.
- eta6
gene engineering:
- Type: DNA vaccine construction
- Description:
- Detailed Gene Information: Click Here.
- DNA vaccine plasmid: pCN3 DNA vaccine plasmid
- Immunization Route: Intramuscular injection (i.m.)
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Host Response |
Fish Response
- Vaccine Immune Response Type: VO_0003057
- Efficacy: Upon exposure to TX1 challenge, the cumulative mortalities of the pCE6-, pCN3-, and PBS-vaccinated fish were 25%, 90%, and 95%, respectively. Therefore, compared to vaccination with pCN3, vaccination with pCE6 produced a RPS of 72%, which is significantly higher than that produced by pEta6 (Jiao et al., 2009).
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References |
Jiao et al., 2009: Jiao XD, Zhang M, Hu YH, Sun L. Construction and evaluation of DNA vaccines encoding Edwardsiella tarda antigens. Vaccine. 2009; 27(38); 5195-5202. [PubMed: 19596416].
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