• Vaccine Name: E. tarda DNA vaccine pCE18
• Target Pathogen: Edwardsiella tarda
• Vaccine Ontology ID: VO_0004556
• Type: DNA vaccine
• Status: Research
• Host Species as Laboratory Animal Model: Japanese flounder
• Antigen: FliC-Et18 fusion protein from E. tarda TX1 (Jiao et al., 2009)
• et18 gene engineering:
  • Type: DNA vaccine construction
  • Description:
  • Detailed Gene Information: Click Here.
• fliC gene engineering:
  • Type: DNA vaccine construction
  • Description:
  • Detailed Gene Information: Click Here.
• DNA vaccine plasmid: pCN3 DNA vaccine plasmid
  • DNA vaccine plasmid name: pCN3 DNA vaccine plasmid
  • DNA vaccine plasmid VO ID: VO_0000992
• Immunization Route: Intramuscular injection (i.m.)

Fish Response

• Vaccine Immune Response Type: VO_0003057
• Efficacy: Following TX1 challenge, fish immunized with pCE18, pCN3 (plasmid), and PBS exhibited cumulative mortalities of 35%, 90%, and 95%, respectively. Hence, with pCN3 as a control, the protective efficacy of pCE18 was 61% in terms of RPS (Jiao et al., 2009).