• Vaccine Name: Foot-and-Mouth Disease Virus Cationic Microparticle-coated DNA Vaccine
• Target Pathogen: Foot-and-mouth disease virus
• Target Disease: Foot-and-mouth disease
• Vaccine Ontology ID: VO_0004552
• Type: DNA vaccine
• Status: Research
• 1D gene engineering:
  • Type: DNA vaccine construction
  • Description:
  • Detailed Gene Information: Click Here.
• DNA vaccine plasmid:
  • DNA vaccine plasmid name:
  • DNA vaccine plasmid VO ID: VO_0000995
• Immunization Route: Intramuscular injection (i.m.)

Guinea pig Response

• Vaccination Protocol: Sixty male guinea pigs of 10 weeks of age were divided in to three groups each containing 20 animals. Group I was inoculated with a 10 µg of pVAC- 1D (naked DNA vaccinated group), group II was inoculated with pVAC-1D coated on PLG microparticles (pVAC-1D + PLG group) and group III received PBS. All the animals were inoculated intramuscularly in the gluteal region of the right leg (Reddy et al., 2012).
• Vaccine Immune Response Type: VO_0003057
• Immune Response: Immunization with pVAC 1D-PLG elicited significantly enhanced neutralization antibody responses compared to naked DNA vaccine (Reddy et al., 2012).
• Efficacy: Microparticles coated plasmid DNA-injected guinea pigs were protected when challenged with FMD virus (Reddy et al., 2012).