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Vaccine Detail

Foot-and-Mouth Disease Virus DNA Vaccine pSinCMV-Vac-MEG990
Vaccine Information
  • Vaccine Name: Foot-and-Mouth Disease Virus DNA Vaccine pSinCMV-Vac-MEG990
  • Target Pathogen: Foot-and-mouth disease virus
  • Target Disease: Foot-and-mouth disease
  • Vaccine Ontology ID: VO_0004551
  • Type: DNA vaccine
  • Status: Research
  • Antigen: the FMDV-specific MEG990 gene - 3 VP1 genes (Dar et al., 2012)
  • 1D gene engineering:
    • Type: DNA vaccine construction
    • Description:
    • Detailed Gene Information: Click Here.
  • 1D gene engineering:
    • Type: DNA vaccine construction
    • Description:
    • Detailed Gene Information: Click Here.
  • 1D gene engineering:
    • Type: DNA vaccine construction
    • Description:
    • Detailed Gene Information: Click Here.
  • DNA vaccine plasmid:
    • DNA vaccine plasmid name:
    • DNA vaccine plasmid VO ID: VO_0000997
  • Immunization Route: Intramuscular injection (i.m.)
Host Response

Guinea pig Response

  • Vaccination Protocol: Immunization of guinea pigs with the construct at dose rate of 10, 5, 2 and 1 μg per animal was through an intramuscular route (Dar et al., 2012).
  • Vaccine Immune Response Type: VO_0003057
  • Immune Response: Immune responses included significant neutralizing antibody induction at all doses against all serotypes tested as compared to non-immunized controls, and delayed appearance and reduced severity of FMD lesions (Dar et al., 2012).
  • Challenge Protocol: Viral challenge of guinea pigs was 4 week post-immunization with 1000 GPID(50) of FMDV serotype A (Dar et al., 2012).
  • Efficacy: Two of six and one of six guinea pigs were completely protected in 10 and 5 μg immunized groups (Dar et al., 2012).
References