• Vaccine Name: Foot-and-Mouth Disease Virus DNA Vaccine pSinCMV-Vac-MEG990
• Target Pathogen: Foot-and-mouth disease virus
• Target Disease: Foot-and-mouth disease
• Vaccine Ontology ID: VO_0004551
• Type: DNA vaccine
• Status: Research
• Antigen: the FMDV-specific MEG990 gene - 3 VP1 genes (Dar et al., 2012)
• 1D gene engineering:
  • Type: DNA vaccine construction
  • Description:
  • Detailed Gene Information: Click Here.
• 1D gene engineering:
  • Type: DNA vaccine construction
  • Description:
  • Detailed Gene Information: Click Here.
• 1D gene engineering:
  • Type: DNA vaccine construction
  • Description:
  • Detailed Gene Information: Click Here.
• DNA vaccine plasmid:
  • DNA vaccine plasmid name:
  • DNA vaccine plasmid VO ID: VO_0000997
• Immunization Route: Intramuscular injection (i.m.)

Guinea pig Response

• Vaccination Protocol: Immunization of guinea pigs with the construct at dose rate of 10, 5, 2 and 1 μg per animal was through an intramuscular route (Dar et al., 2012).
• Vaccine Immune Response Type: VO_0003057
• Immune Response: Immune responses included significant neutralizing antibody induction at all doses against all serotypes tested as compared to non-immunized controls, and delayed appearance and reduced severity of FMD lesions (Dar et al., 2012).
• Challenge Protocol: Viral challenge of guinea pigs was 4 week post-immunization with 1000 GPID(50) of FMDV serotype A (Dar et al., 2012).
• Efficacy: Two of six and one of six guinea pigs were completely protected in 10 and 5 μg immunized groups (Dar et al., 2012).