• Vaccine Name: Feline immunodeficiency virus recombinant vector vaccine FIVΔRT
• Target Pathogen: Feline immunodeficiency virus
• Target Disease: Feline AIDS
• Vaccine Ontology ID: VO_0004550
• Type: Recombinant vector vaccine
• Status: Research
• Immunization Route: Intramuscular injection (i.m.)

Cat Response

• Vaccination Protocol: Kittens, which were 12 weeks old, were randomized into groups of five for immunization. DNA was administered at four sites in the gastrocnemius and quadriceps muscles (100 μg of each DNA in a total of 200 μl of PBS at each site) (Hosie et al., 1998).
• Vaccine Immune Response Type: VO_0003057
• Immune Response: The bias toward CTL induction rather than antibody production in response to inoculation with FIVΔRT suggested that intramuscular administration of the FIVΔRT DNA generated primarily a Th1-type immune response (Hosie et al., 1998).
• Challenge Protocol: The cats were challenged with the homologous F-14 molecular clone of the FIV-PET isolate that had been subjected to titer determination by intraperitoneal inoculation of age-matched cats to calculate the 50% infectious dose (Hosie et al., 1998).
• Efficacy: At 6, 9, and 12 weeks postchallenge, one of five FIVΔRT vaccinates and three of five FIVΔRT-plus-IFN-γ vaccinates remained virus free. In contrast, virus was isolated consistently from all of the control cats (IFN-γ alone and no-DNA control groups) at 6, 9, and 12 weeks postchallenge (Hosie et al., 1998).