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Vaccine Detail
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P. multocida DNA vaccine pcDNA-OMPH + pcDNA-OMPA |
| Vaccine Information |
- Vaccine Name: P. multocida DNA vaccine pcDNA-OMPH + pcDNA-OMPA
- Target Pathogen: Pasteurella multocida
- Target Disease: Pasteurellosis, fowl cholera
- Vaccine Ontology ID: VO_0004536
- Type: DNA vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Chickens
- OmpA
gene engineering:
- Type: DNA vaccine construction
- Description:
- Detailed Gene Information: Click Here.
- ompH
gene engineering:
- Type: DNA vaccine construction
- Description:
- Detailed Gene Information: Click Here.
- DNA vaccine plasmid: pcDNA3.1 DNA vaccine plasmid
- Immunization Route: Intramuscular injection (i.m.)
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| Host Response |
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Chicken Response
- Vaccine Immune Response Type: VO_0000286
- Immune Response: A significant increase in serum antibody levels was observed in chickens vaccinated with divalent combination. Additionally, the lymphocyte proliferation (SI value) and the levels of IFN-γ were both higher in chickens immunized with divalent combination than in those vaccinated with monovalent DNA vaccines (P<0.05) (Gong et al., 2013).
- Efficacy: The protection provided by divalent combination vaccine was superior to that provided by monovalent DNA vaccines after challenging with the avian P. multocida strain CVCC474 (Gong et al., 2013).
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| References |
Gong et al., 2013: Gong Q, Qu N, Niu M, Qin C, Cheng M, Sun X, Zhang A. Immune responses and protective efficacy of a novel DNA vaccine encoding outer membrane protein of avian Pasteurella multocida. Veterinary immunology and immunopathology. 2013; 152(3-4); 317-324. [PubMed: 23340446].
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