• Vaccine Name: IBDV DNA vaccine pCAGVP243-IL-18
• Target Pathogen: Infectious Bursal Disease Virus (IBDV)
• Target Disease: Infectious Bursal Disease
• Vaccine Ontology ID: VO_0004534
• Type: DNA vaccine
• Status: Research
• Host Species as Laboratory Animal Model: Chickens
• Antigen: VP243 gene of vvIBDV HLJ0504 (VP243 can be cleaved into VP2, VP3, and VP4) (Li et al., 2013)
• VP2-VP4-VP3 gene engineering:
  • Type: DNA vaccine construction
  • Description:
  • Detailed Gene Information: Click Here.
• DNA vaccine plasmid: Pcaggs DNA vaccine plasmid
  • DNA vaccine plasmid name: Pcaggs DNA vaccine plasmid
  • DNA vaccine plasmid VO ID: VO_0000099
• Immunization Route: Intramuscular injection (i.m.)

Chicken Response

• Immune Response: Chickens immunized with plasmid pCAGVP243-IL-18 carrying both VP243 and IL-18 genes induced significantly higher levels of antibodies, lymphocyte proliferation responses and of the cytokines IL-4 and IFN-γ than those injected with pCAGVP243 encoding the VP243 gene alone (Li et al., 2013).
• Efficacy: Furthermore, pCAGVP243-IL-18 provided higher protection (93%) against vvIBDV challenge in chickens than pCAGVP243 (60%), as evidenced by the absence of clinical signs, mortality, and bursal atrophy (Li et al., 2013).